The creativity of cabinetry handle designers is wonderful, don't you think? Just searching today, we came across these lovely handles called "Copia Bronze" (credit: myknobs.com)

One of the things we've learned is to watch knobs of a certain shape, ie. box handles, or triangular, or any type that needs to be set in a certain way. They never stay that way; they twist in everyday use, so if you're a "precision-ist" like our designer, Kelly, you're compelled to straighten every single knob when you walk into the room.
Round knobs aren't a problem; if they twist, you certainly don't see it, unless they have a certain pattern, say grapes or leaves which look better in an upright position.
Some companies have thought the product through and added one or two small bumps on the back side or mounting plate of the handle; thus, when the knob is screwed into the drawer/door, the bumps dig into the drawer front, locking the knob into place. Or some knobs have two screws instead of one.
We don't know if the Copia Bronze leaf knobs have them (unfortunately, not a lot do) but at least you now know what to look for.

(Rather grainy picture above, but it shows some handles we did for fun on a small dining hutch - they're wine bottles and glasses and they didn't have the anti-twist bumps.
On the other hand, they could serve as a message to guests: once the bottles tilt 180 degrees, it's time to go home.)